PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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However, the use of 0. Date range on this day between these dates. Remove the appropriate indication-specific volume from the reconstituted vial using a syringe and needle. Keeping the vial of Sterile Ppackage for Injection upright, insert the piercing pin of the transfer device provided by the manufacturer vertically into the center of the stopper.

Pwckage Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation.

Click “OK” if you are a healthcare professional. Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Alteplase is not approved by the FDA to be prepared as cryopreserved bolus injections.

Agree with leaving cath flow cathfli minutes if doesn’t clear out the first time.

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Prothrombin times stabilized during administration of both agents will change slightly when heparin is discontinued. The link you have selected will take packagee away from this site to one that is not owned or controlled by Genentech, Inc. Following instillation of second dose, check catheter function 30 minutes and, if needed, minutes following second instillation.

Infections Cathflo Activase should be used with caution in oackage presence of known or suspected infection in the catheter. Monitor patients treated with alteplase during and for several hours after the end of infusion.


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Length of infusion depends upon indication. I must ask the question as I am hearing lots of rumble from my in-patient colleagues about 24 hour dwell time.

For multiple lumens, treat one lumen at a time. This thread catbflo has a best answer. Pre-treatment with oral anticoagulants is reported to be an independent risk factor for intracranial hemorrhage in thrombolytic-treated patients.

Although we only use a total of 2 Alteplase doses in a 24hr time period.

Long-term studies in animals have not been performed to evaluate the carcinogenic potential or the effect on fertility. Potential interactions between Cathflo Activase and laboratory tests have not pcakage studied. The INS Infusion Therapy Standards of Practice state that the instillation of alteplase 2 mg Cathflo Activase is safe and effective in restoring catheter patency in patients.

Severe Due to the increased bleeding risk, avoid concurrent use of apixaban with thrombolytic agents. Sodium Hyaluronate, Hyaluronic Acid: Major Ginkgo biloba should be used pakcage in patients taking thrombolytic agents.

Moderate Since ginger inhibits thromboxane synthetase, a platelet aggregation inducer, and is a prostacyclin agonist, use with caution during times when bleeding is a concern.

In patients with acute ischemic stroke with uncontrolled hypertension who are otherwise eligible for alteplase therapy, increase the frequency of blood pressure monitoring if systolic blood pressure is more than mmHg or diastolic blood pressure is more than mmHg. However, an increase in INR from 2.

Single-Use Vial Lytic Thrombolytic – Cathflo® Activase® (alteplase)

Moderate Icosapent ethyl is an ethyl ester of the omega-3 fatty acid eicosapentaenoic acid EPA. Infants, Children, and Adolescents. We get a dye study for any port that does not have a blood return and use them insetr the radiologist’ report states they are in the proper place and ok to use.


I hope that helps. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever insdrt and container permit. Patients receiving warfarin that initiate concomitant icosapent ethyl therapy should have their INR monitored more closely and the dose pqckage warfarin adjusted accordingly.

Moderate Platelet aggregation may be impaired by selective serotonin reuptake inhibitors SSRIs due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication in patients receiving thrombolytic agents. It is unknown whether alteplase crosses the placenta or is excreted into breast milk. In many cases, patients received concomitant ACE inhibitors.

Major Concomitant administration of platelet inhibitors and thrombolytic agents could theoretically result in an increased risk of bleeding due to additive pharmacodynamic effects, and combinations of these agents should be approached with caution.

Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase.

Consider other reasons for catheter dysfunction, such as catheter malposition, mechanical failure, constriction by a suture, and lipid deposits or drug precipitates within the lumen, before treatment with alteplase. Complete dissolution should occur within 3 minutes. Children and Adolescents weighing 30 kg or more.

Central Venous Catheter Instillation Administration Alteplase is instilled into the occluded lumen of a central venous catheter. Guidelines suggest tube thoracostomy with or without subsequent fibrinolytic instillation should be attempted as the initial treatment of an empyema in pediatric patients.

If wait time is an iss